TDI-2760 | Aβ aggregation inhibitor | Probechem Biochemicals

Chemical Structure : TDI-2760

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TDI-2760 (TDI2760)

货号: PC-63202Not For Human Use, Lab Use Only.

TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process.

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生物&药学活性

TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process.
TDI-2760 restores the Aβ42-induced decrease in fibrin clot turbidity without affecting normal clotting in an in vitro clotting assay.
TDI-2760 effectively inhibits Aβ42 fibrillization and modulates Aβ42-induced contact system activation.

物理化学性质&存储条件

分子量	306.369
分子式	C18H18N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(dimethylamino)phenoxy)-N-phenylpyrimidin-2-amine

参考文献

1. Singh PK, et al. Biochemistry. 2018 Feb 27;57(8):1399-1409.

TDI-2760 (TDI2760)

生物&药学活性

物理化学性质&存储条件

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TDI-2760 (TDI2760)

生物&药学活性

物理化学性质&存储条件

参考文献

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