TBK1-IN-1

Chemical Structure : TBK1-IN-1

CAS No.: 1292310-49-6

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货号: PC-43042Not For Human Use, Lab Use Only.

TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM.

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10 mg	￥2580	In stock
25 mg	￥4580	In stock
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生物&药学活性

TBK1-IN-1 is a potent, ATP-competitive TBK1 inhibitor, dose-dependently inhibits pIRF3(S386) in Panc 05.04 cells with IC50 of 1.8 nM.
TBK1-IN-1 inhibits IRF3 nuclear translocation with IC50 of 95 nM, but does not significantly inhibits cell proliferation in some NSCLC, pancreatic, and colorectal cell lines.

物理化学性质&存储条件

分子量	457.5243
分子式	C26H27N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 21.5 mg/mL
Chemical Name/SMILES	Benzonitrile, 5-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-2-[(tetrahydro-2H-pyran-4-yl)oxy]-

参考文献

1. Muvaffak A, et al. Mol Cancer Res. 2014 Jul;12(7):1055-66.

TBK1-IN-1

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TBK1-IN-1

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