TBBi (4,5,6,7-tetrabromobenzimidazole, TBBz)

Chemical Structure : TBBi

CAS No.: 577779-57-8

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货号: PC-61326Not For Human Use, Lab Use Only.

TBBi (4,5,6,7-tetrabromobenzimidazole, TBBz) is a potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TBBi (4,5,6,7-tetrabromobenzimidazole, TBBz) is a potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM.
TBBi weakly inhibits CK1 (about 100-fold less potent), and has no activity for PKA and PKC.
TBBi decreases the activity of GBM-initiating cell regulator β-catenin, reduces cell growth, decreases tumor size, and increases survival rates in GBM xenograft mouse models.

物理化学性质&存储条件

分子量	433.72
分子式	C7H2N2Br4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,5,6,7-Tetrabromo-1H-benzimidazole

参考文献

1. Zień P, et al. Biochem Biophys Res Commun. 2003 Jun 20;306(1):129-33.

2. Zien P, et al. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):271-80.

3. Nitta RT, et al. Oncogene. 2015 Jul;34(28):3688-99.