TAK-441 |CAS:1186231-83-3 Probechem Biochemicals

Chemical Structure : TAK-441

CAS No.: 1186231-83-3

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TAK-441 (TAK 441;TAK441)

货号: PC-60477Not For Human Use, Lab Use Only.

TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

TAK-441 is a highly potent, orally active hedgehog signaling (Hh) inhibitor with IC50 of 4.4 nM in Gli-luc reporter assays.
TAK-441 suppresses transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibits tumor growth in mouse medulloblastoma allograft model.

物理化学性质&存储条件

分子量	576.56
分子式	C28H31F3N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

参考文献

1. Ohashi T, et al. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17.

TAK-441 (TAK 441;TAK441)

生物&药学活性

物理化学性质&存储条件

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TAK-441 (TAK 441;TAK441)

生物&药学活性

物理化学性质&存储条件

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