TAI-95 (T-1101) | Hec1-Nek2 inhibitor | Probechem Biochemicals

Chemical Structure : TAI-95

CAS No.: 1438638-83-5

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TAI-95 (T-1101, TAI95)

货号: PC-61482Not For Human Use, Lab Use Only.

TAI-95 (T-1101, TAI 95) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).

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生物&药学活性

TAI-95 (T-1101, TAI 95) is a potent, orally abioavailable Hec1 inhibitor that disrupts Hec1-Nek2 protein interaction wide anti-cancer spectrum (GI50=14.29-73.65 nM, breast cancer cell lines).
TAI-95 (T-1101) demonstrates strong inhibition of in vivo tumor growth of breast cancer models without inducing weight loss or other obvious toxicity.
TAI-95 (T-1101) induces apoptotic cell death, shows activity on MDR cell lines and leads to downregulation of the expression of P-glycoprotein (Pgp),.
TAI-95 (T-1101) also increases the potency of cytotoxic Pgp substrates, including doxorubicin and topotecan.

物理化学性质&存储条件

分子量	493.6
分子式	C24H23N5O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-(4-{[5-(2-methoxyethoxy)pyrazine-2-yl]thio}-2,6-dimethylphenyl) thiazol-2-yl]isonicotinamide

参考文献

1. Huang LY, et al. Mol Cancer Ther. 2014 Jun;13(6):1419-30.

2. Huang LY, et al. Cancer Chemother Pharmacol. 2014 Sep;74(3):511-20.

TAI-95 (T-1101, TAI95)

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物理化学性质&存储条件

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TAI-95 (T-1101, TAI95)

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物理化学性质&存储条件

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