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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-T7117
T7117

Chemical Structure : T7117

CAS No.: 69056-38-8

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T7117 (6R-BH4 dihydrochloride, Sapropterin dihydrochloride)

货号: PC-26612Not For Human Use, Lab Use Only.

T7117 (6R-BH4 dihydrochloride) is a specific small molecule inhibitor that disrupts the TRIM25-HIF-1α interaction, exerts potent anti‑tumor effects in GBM, also is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations.

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25 mg ￥980 In stock
100 mg ￥1980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

T7117 (6R-BH4 dihydrochloride) is a specific small molecule inhibitor that disrupts the TRIM25-HIF-1α interaction, exerts potent anti‑tumor effects in GBM, also is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations.

物理化学性质&存储条件

分子量 314.17
分子式 C9H17Cl2N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride

参考文献

1. Hui Huang, et al. Cell Death Dis. 2026 Apr 22. doi: 10.1038/s41419-026-08757-3.

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