T2M-010

Chemical Structure : T2M-010

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货号: PC-25596Not For Human Use, Lab Use Only.

T2M-010 is a potent small molecule binder of Triggering receptor expressed on myeloid cells 2 (TREM2) with MST KD of 0.83 uM, functions as an activator of TREM2 signaling.

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250 mg		Get quote

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生物&药学活性

T2M-010 is a potent small molecule binder of Triggering receptor expressed on myeloid cells 2 (TREM2) with MST KD of 0.83 uM, functions as an activator of TREM2 signaling.
T2M-010 (25 uM) led to a robust twofold increase in SYK phosphorylation, a canonical downstream readout of TREM2 activation in HEK–hTREM2/DAP12 cells.
T2M-010 significantly enhanced bead uptake, demonstrating a marked increase in phagocytic activity that paralleled the effect of VG-3927, in BV2 cells.
T2M-010 shows capacity to recapitulate protective microglial programs previously linked to genetic or antibody-mediated TREM2 activation.

物理化学性质&存储条件

分子量	319.43
分子式	C19H17N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1H-indol-3-yl)-N-phenethylthiazol-2-amine

参考文献

1. Cho S, et al. bioRxiv [Preprint]. 2025 Sep 17:2025.09.11.675743.

T2M-010

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物理化学性质&存储条件

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T2M-010

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物理化学性质&存储条件

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