T1742

Chemical Structure : T1742

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货号: PC-24643Not For Human Use, Lab Use Only.

T1742 is a small molecule ATG5 inhibitor, blocks the ATG5-ATG16L1 and ATG5-TECAIR interactions in vitro (IC50=1-2 uM), effectively inhibits autophagy in living cells.

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100 mg		Get quote

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生物&药学活性

T1742 is a small molecule ATG5 inhibitor, blocks the ATG5-ATG16L1 and ATG5-TECAIR interactions in vitro (IC50=1-2 uM), effectively inhibits autophagy in living cells.
T1742 treatment (5-40 uM) caused a significant decrease in the LC3B-II level in COS-7, U-937 and THP-1 cells.
T1742 is the first small-molecule autophagy inhibitor that disrupts the protein-protein interactions involving ATG5.

物理化学性质&存储条件

分子量	478.46
分子式	C28H18N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(3-((5-(4-nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid

参考文献

1. Xiang H, et al. Autophagy Rep. 2023 May 27;2(1):2215617.

T1742

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T1742

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物理化学性质&存储条件

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