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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-T111
T111

Chemical Structure : T111

CAS No.: 2460475-74-3

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T111

货号: PC-25133Not For Human Use, Lab Use Only.

T111 is a potent acridone antimalarial inhibitor against blood, liver, and mosquito stages of malaria parasite, inhibits mitochondrial electron transport chain, has IC50 of 0.028, 0.11 and 0.11 nM for P. falciparum strains Dd2, DR1, and DR4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

T111 is a potent acridone antimalarial inhibitor against blood, liver, and mosquito stages of malaria parasite, inhibits mitochondrial electron transport chain, has IC50 of 0.028, 0.11 and 0.11 nM for P. falciparum strains Dd2, DR1, and DR4.

物理化学性质&存储条件

分子量 423.75
分子式 C20H10ClF4NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-chloro-1-fluoro-6-(4-(trifluoromethoxy)phenoxy)acridin-9(10H)-one

参考文献

1. Kelly J, et al. Res Sq [Preprint]. 2025 Jun 27:rs.3.rs-6858328.

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