T-025 (T025) | CLK inhibitor | Probechem Biochemicals

Chemical Structure : T-025

CAS No.: 2407433-00-3

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T-025 (T025, CLK inhibitor T-025)

货号: PC-35047Not For Human Use, Lab Use Only.

T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM.
T-025 reduces CLK-dependent phosphorylation, induces skipping exon, resulting in anti-proliferative effect in MDA-MB-468 in vitro and in vivo accompanied by the modulation of pre-mRNA splicing.
T-025 shows sensitivity against high CLK2 expression or MYC amplification cancer celles.
T-025 exhibits significant anti-tumor efficacy in MYC-driven breast tumor allograft models.

物理化学性质&存储条件

分子量	382.431
分子式	C21H18N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

参考文献

1. Iwai K, et al. EMBO Mol Med. 2018 May 16. pii: e8289.

T-025 (T025, CLK inhibitor T-025)

生物&药学活性

物理化学性质&存储条件

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T-025 (T025, CLK inhibitor T-025)

生物&药学活性

物理化学性质&存储条件

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