Synucleozid-2.0 | α-synuclein inhibitor | Probechem Biochemicals

Chemical Structure : Synucleozid-2.0

CAS No.: 613226-91-8

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Synucleozid-2.0 (Synucleozid 2.0)

货号: PC-21679Not For Human Use, Lab Use Only.

Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA, binds to the IRE of SNCA mRNA with EC50 of 2.9 µM and Kd value of 1.8 uM.

规格	价格	库存
1 mg	￥1780	In stock
2 mg	￥2780	In stock
5 mg	￥4980	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA, binds to the IRE of SNCA mRNA with EC50 of 2.9 µM and Kd value of 1.8 uM.

Synucleozid-2.0 selectively binds to and stabilizes the A bulge and adjacent closed base pairs in the 5' UTR IRE of SNCA mRNA.

Synucleozid-2.0 blocks the translation process and reduces intracellular levels of α-synuclein.

Synucleozid-2.0 exerts cytoprotective effects against cytotoxicity induced by α-synuclein preformed fibrils.

物理化学性质&存储条件

分子量	506.38
分子式	C22H16BrN7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(4-bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(1H-indazol-6-yl)acetamide

参考文献

1. Tong Y, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306682120.

Synucleozid-2.0 (Synucleozid 2.0)

生物&药学活性

物理化学性质&存储条件

参考文献

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Synucleozid-2.0 (Synucleozid 2.0)

生物&药学活性

物理化学性质&存储条件

参考文献

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