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首页-抗体和重组蛋白-Biosimilar Antibody-Sotigalimab
Sotigalimab

Chemical Structure : Sotigalimab

CAS No.: 2305607-45-6

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Sotigalimab (Anti-human CD40 mAb, human IgG1-Kappa; APX005M)

货号: PC-Ab1065Not For Human Use, Lab Use Only.

Sotigalimab (APX005M) is a humanized monoclonal antibody that binds CD40 with high affinity and activates antigen presenting cells (dendritic cells, monocytes and B cells) leading to stimulation of cancer-specific T-cell responses. This CD40 monoclonal antibody with chemotherapy induces T-cell-dependent tumour regression in mice and improves survival, triggers a multifaceted immune response that brings several components of the immune system together to attack the cancer..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sotigalimab (APX005M) is a humanized monoclonal antibody that binds CD40 with high affinity and activates antigen presenting cells (dendritic cells, monocytes and B cells) leading to stimulation of cancer-specific T-cell responses. This CD40 monoclonal antibody with chemotherapy induces T-cell-dependent tumour regression in mice and improves survival, triggers a multifaceted immune response that brings several components of the immune system together to attack the cancer.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Sotigalimab; APX005M; APX-005M; Cluster of Differentiation 40; CD40/TNFR5; CD40-CD40L agonist antibody.

参考文献

1. 1, O'Hara MH, et al. Lancet Oncol. 2021 Jan;22(1):118-131. 2, Filbert EL, et al. Cancer Immunol Immunother. 2021 Jul;70(7):1853-1865. 3, Weiss SA, et al. Clin Cancer Res. 2021 Sep 1;27(17):4757-4767. 4, Djureinovic D, et al. Cancers (Basel). 2021 Mar 15;13(6):1302.

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