Senile plaques (SPs) probe BSB

Chemical Structure : Senile plaques (SPs) probe BSB

CAS No.: 291766-06-8

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货号: PC-38734Not For Human Use, Lab Use Only.

Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM).

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM).
BSB specifically labels SPs in postmortem AD brain sections with excellent fluorescent properties (λab = 340 nm; λem = 520 nm) and lipophilicity.
BSB effectively labels Aβ aggregates in vivo.
BSB shows potential as an antemortem diagnostic for Alzheimer's disease (AD).

物理化学性质&存储条件

分子量	481.298
分子式	C24H17BrO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Bromo-2,5-bis(3-carboxy-4-hydroxystyryl)benzene

参考文献

1. D M Skovronsky, et al. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7609-14.