Senexin A | CDK8/CDK19 inhibitor | Probechem Biochemicals

Chemical Structure : Senexin A

CAS No.: 1366002-50-7

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Senexin A (Senexin A)

货号: PC-44628Not For Human Use, Lab Use Only.

Senexin A is a selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19, inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

Senexin A is a selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19, inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively.
Senexin A inhibits only p21-induced transcription but not other biological effects of p21, inhibits β-catenin-dependent transcription in HCT116 colon carcinoma cells.
Senexin A suppresses damage-induced tumor-promoting paracrine activities of tumor cells and normal fibroblasts.
Senexin A reverses the increase in tumor engraftment and serum mitogenic activity in mice pretreated with doxorubicin.

物理化学性质&存储条件

分子量	274.32
分子式	C17H14N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥100 mg/mL
Chemical Name/SMILES	6-Quinazolinecarbonitrile, 4-[(2-phenylethyl)amino]-

参考文献

1. Porter DC, et al. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804.

2. McDermott MS, et al. Oncotarget. 2017 Feb 21;8(8):12558-12575.

Senexin A (Senexin A)

生物&药学活性

物理化学性质&存储条件

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Senexin A (Senexin A)

生物&药学活性

物理化学性质&存储条件

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