Selonsertib (GS-4997) | ASK1 inhibitor | Probechem Biochemicals

Chemical Structure : Selonsertib

CAS No.: 1448428-04-3

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Selonsertib (GS-4997, GS4997)

货号: PC-45565Not For Human Use, Lab Use Only.

Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with pIC50 of 8.3.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

Selonsertib (GS-4997) is a highly selective and potent, ATP-competetive inhibitor of ASK1 (Apoptosis Signal-regulating Kinase 1, MAP3K5) with pIC50 of 8.3.

Selonsertib (GS-4997) antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.

Selonsertib (GS-4997) with potential anti-inflammatory, antineoplastic and anti-fibrotic activities; orally bioavailable.

物理化学性质&存储条件

分子量	445.4921
分子式	C24H24FN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Benzamide, 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

参考文献

1. Lin JH, et al. Nephron. 2015;129(1):29-33.
2. Ji N, et al. Cancer Lett. 2019 Jan;440-441:82-93.

Selonsertib (GS-4997, GS4997)

生物&药学活性

物理化学性质&存储条件

参考文献

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Selonsertib (GS-4997, GS4997)

生物&药学活性

物理化学性质&存储条件

参考文献

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