SecA activator HSI6 (HSI#6)

Chemical Structure : SecA activator HSI6

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货号: PC-26035Not For Human Use, Lab Use Only.

SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

SecA activator HSI#6 is a small molecule, specific and allosteric activator of SecA dependent secretion, binds onto SecA and allosterically activates the translocase with AC50 of 3.76 uM, activates the soluble, membrane-bound and at-translocation-site SecA states.
HSI#6 (10 uM) has barely an effect on the basal, stimulates the membrane ATPase by ~3folds and no effect on the translocation.
HSI#6 has not affect the in vitro activity of other enzyme as DnaK, Alkaline phosphatase.
HSI#6 affects all forms of the enzyme; soluble, membrane-bound and 'at-translocation'.
HSI#6 enhances SecA dependent preprotein secretion, in vivo and in vitro.
HSI#6 enhances ADP release from SecA.
HSI#6 activates the translocase by modulating the intrinsic dynamics of SecA.

物理化学性质&存储条件

分子量	340.68
分子式	C10H5ClF4N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-chloro-4-fluorophenyl)-3-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)urea

参考文献

1. Sedky H, et al. Commun Biol. 2026 Feb 6. doi: 10.1038/s42003-026-09623-w.