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首页-小分子抑制剂&激动剂-GPCR-TGR5 (GPCR19, GPR131, GPBAR1)-Sauchinone
Sauchinone

Chemical Structure : Sauchinone

CAS No.: 177931-17-8

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Sauchinone

货号: PC-24477Not For Human Use, Lab Use Only.

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis with anti-inflammatory and antioxidant activity, inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation, also is a novel TGR5 agonist.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis with anti-inflammatory and antioxidant activity, inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation, also is a novel TGR5 agonist.

物理化学性质&存储条件

分子量 356.37
分子式 C20H20O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5aR,5a1R,7R,8S,8aR,14aS)-7,8-Dimethyl-5a,5a1,6,7,8,8a-hexahydro-5H-benzo[kl]bis([1,3]dioxolo)[4,5-b:4',5'-g]xanthen-5-one

参考文献

1. Lee AK, et al. Br J Pharmacol. 2003 May;139(1):11-20.

2. Wang HY, et al. J Adv Res. 2025 Apr 22:S2090-1232(25)00278-4.

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