Salinomycin | Ferroptosis inducer | Probechem Biochemicals

Chemical Structure : Salinomycin

CAS No.: 53003-10-4

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Salinomycin (Procoxacin)

货号: PC-23010Not For Human Use, Lab Use Only.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells.
Salinomycin sodium inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.
Salinomycin sodium induces ER stress‑mediated autophagy and apoptosis through generation of ROS in human glioma U87MG cells.

物理化学性质&存储条件

分子量	751.01
分子式	C42H70O11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid

参考文献

1. Mitani M, et al. Antimicrob Agents Chemother. 1976 Apr;9(4):655-60.

2. Lu D, et al. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.

3. Yu SN, et al. Oncol Rep. 2017 Jun;37(6):3321-3328.

Salinomycin (Procoxacin)

生物&药学活性

物理化学性质&存储条件

参考文献

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Salinomycin (Procoxacin)

生物&药学活性

物理化学性质&存储条件

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