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首页-抗体和重组蛋白-Biosimilar Antibody-Sacituzumab
Sacituzumab

Chemical Structure : Sacituzumab

CAS No.: 1796566-95-4

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Sacituzumab (Anti-human TACSTD2 mAb, human IgG1-Kappa)

货号: PC-Ab1045Not For Human Use, Lab Use Only.

Sacituzumab is a human Trop-2 mAB that targets the Trop-2 protein and attaches to it. Sacituzumab govitecan is an antibody–drug conjugate composed of an antibody targeting the human trophoblast cell-surface antigen 2 (Trop-2), which is expressed in the majority of breast cancers, coupled to SN-38 (topoisomerase I inhibitor) through a proprietary hydrolyzable linker..

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5 mg ￥7580 In stock
10 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sacituzumab is a human Trop-2 mAB that targets the Trop-2 protein and attaches to it. Sacituzumab govitecan is an antibody–drug conjugate composed of an antibody targeting the human trophoblast cell-surface antigen 2 (Trop-2), which is expressed in the majority of breast cancers, coupled to SN-38 (topoisomerase I inhibitor) through a proprietary hydrolyzable linker.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Sacituzumab; Sacituzumab Govitecan; TACSTD2; Trop-2; trophoblast cell-surface antigen 2; Tumor Associated Calcium Signal Transducer 2

参考文献

1. 1, Bardia A, et al. N Engl J Med. 2019 Feb 21;380(8):741-751. 2, Fenn KM, et al. Drugs Today (Barc). 2019 Sep;55(9):575-585.  3, Goldenberg DM, et al. MAbs. 2019 Aug/Sep;11(6):987-995.  4, Kalinsky K, et al. Ann Oncol. 2020 Dec;31(12):1709-1718.

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