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首页-抗体和重组蛋白-Biosimilar Antibody-Sabatolimab
Sabatolimab

Chemical Structure : Sabatolimab

CAS No.: 2252262-24-9

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Sabatolimab (Anti-human Tim-3 mAb, human IgG4 (S228P)-Kappa)

货号: PC-Ab1017Not For Human Use, Lab Use Only.

Binds and blocks the interaction TIM3/PtdSer (Kd=0.16 nM, PtdSer Blocking IC50=6.4 nM) , restore effector T cell activity to promote antitumor immunity by altering myeloid cells in tumor microenvironment. TIM-3 may synergize with PD-1 blockade by enhancing or altering the innate immune response and may form part of a resistance mechanism to PD-1 blockade..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Binds and blocks the interaction TIM3/PtdSer (Kd=0.16 nM, PtdSer Blocking IC50=6.4 nM) , restore effector T cell activity to promote antitumor immunity by altering myeloid cells in tumor microenvironment. TIM-3 may synergize with PD-1 blockade by enhancing or altering the innate immune response and may form part of a resistance mechanism to PD-1 blockade.

物理化学性质&存储条件

分子量
分子式 Human IgG4 (S228P)-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

MBG453; MBG 453; Sabatolimab; T-cell immunoglobulin domain and mucin domain-3; Tim-3; Anti-humanTIM3

参考文献

1. 1, Curigliano G, et al. Clin Cancer Res. 2021 Jul 1;27(13):3620-3629.  2, Bewersdorf JP, et al. Expert Rev Hematol. 2020 Oct;13(10):1131-1142.

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