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首页-小分子抑制剂&激动剂-Apoptosis-Receptor Interacting Protein Kinase (RIPK)-SZM594
SZM594

Chemical Structure : SZM594

CAS No.: 2304617-21-6

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SZM594 (SZM-594)

货号: PC-26713Not For Human Use, Lab Use Only.

SZM594 (SZM-594) is a highly potent, dual inhibitor of RIPK1 and RIPK3 (RIPK1/3) with IC50 of 97 nM and 77 nM respectively, inhibits TSZ‐induced necroptosis in HT‐29 cells with EC50 of 0.17 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SZM594 (SZM-594) is a highly potent, dual inhibitor of RIPK1 and RIPK3 (RIPK1/3) with IC50 of 97 nM and 77 nM respectively, inhibits TSZ‐induced necroptosis in HT‐29 cells with EC50 of 0.17 uM.

物理化学性质&存储条件

分子量 529.51
分子式 C26H19F4N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

参考文献

1. Chen X, et al. Br J Pharmacol. 2019 Jun;176(12):2095-2108.

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