SZM-1209 | RIPK1 inhibitor | Probechem Biochemicals

Chemical Structure : SZM-1209

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SZM-1209 (SZM1209)

货号: PC-24512Not For Human Use, Lab Use Only.

SZM-1209 is a potent, specific RIPK1 inhibitor with Kd value of 85 nM, >100-fold selective over RIPK3, exhibits anti-necroptosis activity against human HT-29 cells with EC50 of 22.4 nM.

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生物&药学活性

SZM-1209 is a potent, specific RIPK1 inhibitor with Kd value of 85 nM, >100-fold selective over RIPK3, exhibits anti-necroptosis activity against human HT-29 cells with EC50 of 22.4 nM.
SZM-1209 specifically inhibits necroptosis signaling rather apoptosis, dose-relatedly inhibits necroptosis and almost 100% protectionat 50 nM.
SZM-1209 specifically inhibits phosphorylation of RIPK1-RIPK3-MLKL necroptosis signaling.
SZM-1209 (10 and 20 mg/kg) effectively protect against mTNFα-induced systemic inflammatory response syndrome (SIRS) model in vivo.
SZM-1209 significantly alleviated ALI by reducing pulmonary edema and pathological damage in NNK short-term intratracheal exposure-induced ALI model.

物理化学性质&存储条件

分子量	696.71
分子式	C31H29F5N4O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(ethylsulfonamido)-N-(5-fluoro-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclohexane-1-carboxamide

参考文献

1. Zhang X, et al. J Med Chem. 2023 Apr 13;66(7):5261-5278.

SZM-1209 (SZM1209)

生物&药学活性

物理化学性质&存储条件

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SZM-1209 (SZM1209)

生物&药学活性

物理化学性质&存储条件

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