SZL P1-41 | Skp2 inhibitor | Probechem Biochemicals

Chemical Structure : SZL P1-41

CAS No.: 222716-34-9

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SZL P1-41 (SZL-P1-41)

货号: PC-42099Not For Human Use, Lab Use Only.

SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.
SZL P1-41 specifically diminishes E3-ligase activity of Skp2-SCF complex, but not of other F-box SCF complex.
SZL P1-41 inhibits Skp2-mediated p27 ubiquitination, induced endogenous p27 protein expression in prostate cancer cells.
SZL P1-41 exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.

物理化学性质&存储条件

分子量	420.524
分子式	C24H24N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-

参考文献

1. Chan CH, et al. Cell. 2013 Aug 1;154(3):556-68.

SZL P1-41 (SZL-P1-41)

生物&药学活性

物理化学性质&存储条件

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SZL P1-41 (SZL-P1-41)

生物&药学活性

物理化学性质&存储条件

参考文献

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