SU212 | AMPK activator | Probechem Biochemicals

Chemical Structure : SU212

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SU212 (SU-212)

货号: PC-25684Not For Human Use, Lab Use Only.

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生物&药学活性

SU212 is a small molecule AMPK activator, specifically binds to enolase 1 (ENO1) and induces its degradation, restricting its intracellular localization, selectively induces oxidative phosphorylation and decreases glycolysis in TNBC cells, with no ettect in normal cells.
SU212 induces mitotic phase arrest and apoptosis in TNBC cells.
SU212 inhibits tumour growth, cancer progression and metastasis in vivo.
SU212 strongly inhibits ENO1 protein expression in multiple TNBC cell lines (MDA-MB-231, MDA-MB-468, and EMT6) in a dose-dependent manner.
SU212 promotes ENO1 degradation through both proteasomal and autophagic pathways.
SU212 does not directly inhibit ENO1 enzymatic activity.
SU212 inhibits cellular glycolysis and the mTOR signaling pathway.

物理化学性质&存储条件

分子量	437.49
分子式	C25H27NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-hydroxyethyl)-10-(3,4,5-trimethoxyphenyl)-3,4,6,7,8,10-hexahydro-1H-cyclopenta[g]furo[3,4-b]quinolin-1-one

参考文献

1. Tailor D, et al. Br J Cancer. 2021 Feb;124(3):604-615.

2. Tailor D, et al. Cell Rep Med. 2025 Nov 7:102451.

SU212 (SU-212)

生物&药学活性

物理化学性质&存储条件

参考文献

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SU212 (SU-212)

生物&药学活性

物理化学性质&存储条件

参考文献

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