SU-9516 |CAS:377090-84-1 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-SU-9516

Chemical Structure : SU-9516

CAS No.: 377090-84-1

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SU-9516 (SU9516;SU 9516)

货号: PC-45491Not For Human Use, Lab Use Only.

SU-9516 is a potent, selective CDK2 inhibitor with IC50 of 22 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SU-9516 is a potent, selective CDK2 inhibitor with IC50 of 22 nM.
SU-9516 shows less potent for CDK1/CDK4(IC50=40/200 nM), no inhibition on PKC, EGFR, p38MAPK.
SU-9516 decreases the phosphorylation of pRb, and increases caspase-3 activation.

物理化学性质&存储条件

分子量	241.2453
分子式	C13H11N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-, (3Z)-

参考文献

1. Lane ME, et al. Cancer Res. 2001 Aug 15;61(16):6170-7.

2. Gao N, et al. Mol Pharmacol. 2006 Aug;70(2):645-55.

3. Sarathy A, et al. Mol Ther. 2017 Apr 5. pii: S1525-0016(17)30121-1.

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SU-9516 (SU9516;SU 9516)

生物&药学活性

物理化学性质&存储条件

参考文献

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SU-9516 (SU9516;SU 9516)

生物&药学活性

物理化学性质&存储条件

参考文献

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