欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Epigenetics-HDAC-STR-V-53
STR-V-53

Chemical Structure : STR-V-53

CAS No.: 2798954-66-0

加入收藏

STR-V-53

货号: PC-22104Not For Human Use, Lab Use Only.

STR-V-53 is a novel glycosylated, liver cancer-selective histone deacetylase (HDAC) inhibitor with IC50 of 24.3/60.1/213.43 nM for HDAC1/2/3/6, demonstrates exquisite selective cytotoxicity against human HCC cells.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    STR-V-53 is a novel glycosylated, liver cancer-selective histone deacetylase (HDAC) inhibitor with IC50 of 24.3/60.1/213.43 nM for HDAC1/2/3/6, demonstrates exquisite selective cytotoxicity against human HCC cells.
    STR-V-53 exhibits anti-proliferation effect against Hep-G2 and Huh7 cells with IC50 of 10.4 and 6.25 uM respectively, but lack of growth inhibition effect against other cancer cells in the NCI-60 panel.
    STR-V-53 shows weak inhibition of HDAC 8 and no inhibition of HDAC 11 at the maximum tested concentration of 10 uM.
    STR-V-53 is uptaked by GLUT-2 and blockage of GLUT-2 attenuates the cytotoxicity of STR-V-53 against Hep-G2 HCC cells.
    STR-V-53 upregulates PD-L1 and downregulates PD-1 expression, upregulates CD54 (ICAM-1) in HCC cells.
    STR-V-53 selectively induces apoptosis in HCC cells, causes cell cycle arrest at the S stage.
    STR-V-53 (25, 50 mg/kg, i.p.) effectively suppresses HCC growth in xenograft and murine models of HCC.
    STR-V-53 reprogrammed the T cell responses and prolonged median overall survival in an orthotopic HCC model in immunocompetent mice, when combined with anti-PD1 therapy.

    物理化学性质&存储条件

    分子量 466.49
    分子式 C21H30N4O8
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-hydroxy-7-(4-(4-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-1H-1,2,3-triazol-1-yl)heptanamide

    参考文献

    1. Bocheng Wu, et al. bioRxiv. 2024 Mar 28:2024.03.27.587062.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: