STM9005 | METTL1 inhibitor | Probechem Biochemicals

Chemical Structure : STM9005

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STM9005 (STM-9005, STM 9005)

货号: PC-28674Not For Human Use, Lab Use Only.

STM9005 is a potent, highly specific inhibitor of m7G methyltransferase METTL1, inhibits recombinant METTL1 enzyme activity with an IC50 < 13 nM and SPR Kd of 2 nM, affects METTL1-mediated m7G modification in cancer cells.

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生物&药学活性

STM9005 is a potent, highly specific inhibitor of m7G methyltransferase METTL1, inhibits recombinant METTL1 enzyme activity with an IC50 < 13 nM and SPR Kd of 2 nM, affects METTL1-mediated m7G modification in cancer cells.
STM9005 shows cell penetration and binding to METTL1 in cells with an IC50 of 13 nM in cellular target engagement assays.
STM9005 has no effect on the activity of other RNA-methyltransferases (METTL3/14, METTL16, BCDIN3D, TSG1 and NSUN2).
STM9005 also displays >10,000-fold selectivity for METTL1-WDR4 when tested against a broad panel of 49 RNA-, DNA- and protein-methyltransferases.
STM9005 potently decreases tRNA-Val-m7G in antibody-based m7G detection assays with IC50 of 34 nM.
STM9005 binds to the SAM-binding site of METTL1.
STM9005 causes cellular changes and cell cycle dysregulation in various cancer models (eg. HL-60 cell IC50=7.5 uM).
STM9005 reduces m7G on tRNAs and impacts METTL1 catalytic-dependent mRNA translation.
STM9005 shows anti-tumour activity in a range of cancer models.

物理化学性质&存储条件

分子量	462.33
分子式	C21H21Cl2N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((R)-4-(2-aminooxazolo[4,5-c]pyridin-7-yl)morpholin-2-yl)((S)-6,8-dichloro-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)methanone

参考文献

1. Yankova E, et al. Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers. Nature. 2026 Oct 28. doi: 10.1038/s41586-026-11178-z.

STM9005 (STM-9005, STM 9005)

生物&药学活性

物理化学性质&存储条件

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STM9005 (STM-9005, STM 9005)

生物&药学活性

物理化学性质&存储条件

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