STL127705 (Ku70/80 inhibitor) |CAS:1326852-06-5 Probechem Biochemicals

Chemical Structure : STL127705

CAS No.: 1326852-06-5

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STL127705 (Ku70/80 inhibitor Compound L)

货号: PC-60419Not For Human Use, Lab Use Only.

STL127705 (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay.

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5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

STL127705 (Ku70/80 inhibitor) is a novel small molecule inhibitor of the DNA repair protein Ku70/80, disrupts of Ku70/80-DNA interaction with IC50 of 3.5 uM in EMSA assay.
STL127705 impairs DNA-PKCS autophospho-rylation at the Ser2056 residue, inhibits the Ku-dependent activation of the DNA-PKCS kinase in human cells.
STL127705 synergistically sensitizes human cell lines to radiation treatment, indicating a clear potential to diminish DSB repair.

物理化学性质&存储条件

分子量	437.431
分子式	C22H20FN5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

参考文献

1. Weterings E, et al. DNA Repair (Amst). 2016 Jul;43:98-106.

STL127705 (Ku70/80 inhibitor Compound L)

生物&药学活性

物理化学性质&存储条件

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STL127705 (Ku70/80 inhibitor Compound L)

生物&药学活性

物理化学性质&存储条件

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