STING synergist 67

Chemical Structure : STING synergist 67

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货号: PC-24559Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

STING synergist 67 is a selective STING synergist with EC50 of 20.5 uM, binds to carboxy-terminal domain (CTD) of STING (SPR KD=12.2 uM), amplifies cGAMP-induced pathway activation without inherent agonist properties.
STING synergist 67 binds to various hSTING alleles and mSTING with a low micromolar affinity, demonstrating broad-spectrum binding activity
STING synergist 67 demonstrated stable synergistic effects at low concentrations, reducing the EC50 values of cGAMP by 9.58 and 5.98-fold in human and murine STING cells, respectively.
STING synergist 67 cannot independently induce cytokine secretion in THP-1 cells, but it significantly potentiates cGAMP-mediated cytokine release; in combination with cGAMP, the secretion of IFN-β, CXCL-10, and IL-6 was enhanced by 3.38-fold, 7.10-fold, and 4.16-fold, respectively, compared to cGAMP treatment alone.
STING synergist 67 demonstrated strong antitumor activity, which was further amplified when administered in combination with the cGAMP or PD-L1 antibody.

物理化学性质&存储条件

分子量	353.42
分子式	C21H23NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 2-(2-Methoxy-3,4,7-trimethyl-9-oxoacridin-10(9H)-yl)acetate

参考文献

1. Hou S, et al. J Med Chem. 2025 Apr 29. doi: 10.1021/acs.jmedchem.4c03131.