STING inhibitor THIQi

Chemical Structure : STING inhibitor THIQi

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货号: PC-24980Not For Human Use, Lab Use Only.

STING inhibitor THIQi is a potent, orthosteric STING inhibitor with IC50 of 84 nM in HAQ STING cGAMP displacement assays, inhibits cGAMP-induced IFNβ in PBMCs with IC50 of 29 nM.

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250 mg		Get quote

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生物&药学活性

STING inhibitor THIQi is a potent, orthosteric STING inhibitor with IC50 of 84 nM in HAQ STING cGAMP displacement assays, inhibits cGAMP-induced IFNβ in PBMCs with IC50 of 29 nM.

物理化学性质&存储条件

分子量	491.97
分子式	C28H26ClNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4S)-2-(4-(tert-butyl)-3-chlorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid

参考文献

1. Tony Siu, et al. ACS Med Chem Lett. 2018 Dec 6;10(1):92-97.

2. Xie T, et al. Nat Commun. 2025 Jul 1;16(1):5695.