STING agonist C92

Chemical Structure : STING agonist C92

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货号: PC-27124Not For Human Use, Lab Use Only.

STING agonist C92 is a potent, allosteric hSTING agonist with EC50 of 36.2 nM for enhancement of the association of [3H]cGAMP (1 nM) to STING.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

STING agonist C92 is a potent, allosteric hSTING agonist with EC50 of 36.2 nM for enhancement of the association of [3H]cGAMP (1 nM) to STING.
C92 activates the cGAS/STING pathway in human primary cells.
C92 activates a strong IFN-I response through phosphorylation of STING and IRF3, induces STING protein oligomerization and phosphorylation of STING and IRF3.
C92 (1) does not induce autophagy, (2) does not require downstream trafficking of STING from the ER to Golgi for activation of IRF3, (3) does not reduce levels of STING and, (4) does not promote pyroptosis and hyperinflammation.
Systemic administration of C92 leads to activation of the STING pathway and TGR in vivo.

物理化学性质&存储条件

分子量	505.90
分子式	C25H20ClF4N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(2-chloro-6-fluorobenzyl)-3,4-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide

参考文献

1. Banerjee M, et al. J Immunother Cancer. 2026 Jun 23;14(6):e015242.