STAT3 inhibitor W36

Chemical Structure : STAT3 inhibitor W36

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货号: PC-25250Not For Human Use, Lab Use Only.

STAT3 inhibitor W36 is a potent, selective STAT3 inhibitor with SPR KD of 323.3 nM, inhibits IL-6/JAK/STAT3 signaling pathway with IC50 of 0.87 uM in HEK-Blue-IL-6 cell model.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

STAT3 inhibitor W36 is a potent, selective STAT3 inhibitor with SPR KD of 323.3 nM, inhibits IL-6/JAK/STAT3 signaling pathway with IC50 of 0.87 uM in HEK-Blue-IL-6 cell model.
W36 demonstrates dual suppression of STAT3 phosphorylation and proliferation in the STAT3-overactivated TNBC cell lines MDA-MB-231 (IC50 = 0.61 μM) and MDA-MB-468 (IC50 = 0.65 μM).
W36 displays strong anti-proliferative effects against the taxol-resistant strains MCF-7/T and MX-1/T with IC50 of 1.73 and 0.75 uM respectively.
W36 inhibits STAT3 phosphorylation at Y705 in a dose- and time-dependent manner, but not STAT1 or STAT5.
W36 also shows no activity against classic JAK subfamily kinases (JAK1, JAK2, JAK3, TYK2 and SRC).
W36 inhibits STAT3 Y705 phosphorylation and downstream target gene expression in MDA-MB-231 and MDA-MB-468 cells.
W36 (7.5, 10 mg/kg, i.p.) or (100 mg/kg, p.o.) exhibits antineoplastic efficacy in MDA-MB-231 xenograft model nude mice, potent than Stattic.

物理化学性质&存储条件

分子量	564.69
分子式	C31H29FN8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-((1-cyclopropyl-6-(4-ethylpiperazin-1-yl)-2-(4-fluorophenyl)-1H-benzo[d]imidazol-5-yl)amino)-1,3,4-thiadiazol-2-yl)benzonitrile

参考文献

1. Wang R, et al. Eur J Med Chem. 2025 Aug 5;298:118020.