SRJ23 | Ras inhibitor | Probechem Biochemicals

Chemical Structure : SRJ23

加入收藏

SRJ23 (SRJ-23, SRJ 23)

货号: PC-70353Not For Human Use, Lab Use Only.

SRJ23 is a semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SRJ23 is a semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation.
SRJ23 significantly suppresses K-Ras GTP loading, whereas H-Ras and N-Ras GTP loading are much less sensitive.
SRJ23 reduceds K-RasG12V GTP, phosphorylated ERK (ppERK) levels in K-RasG12V-transformed cells.
SRJ23 induces G1 arrest and apoptosis in MCF-7 and HCT-116 cells, respectively.

物理化学性质&存储条件

分子量	491.00
分子式	C27H32ClFO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2(3H)-Furanone, 3-[2-[(4aR,6aS,7R,10aS,10bR)-3-(3-chloro-4-fluorophenyl)decahydro-6a,10b-dimethyl-8-methylene-1H-naphtho[2,1-d][1,3]dioxin-7-yl]ethylidene]dihydro-4-hydroxy-, (3E,4S)-

参考文献

1. Hocker HJ, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10201-6.

2. Jada SR, et al. Br J Pharmacol. 2008 Nov;155(5):641-54.

3. Wong HC, et al. Cell Biol Toxicol. 2014 Oct;30(5):269-88.

SRJ23 (SRJ-23, SRJ 23)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SRJ23 (SRJ-23, SRJ 23)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.