SRI-011381 (C381) hydrochloride | Smad activator | Probechem Biochemicals

Chemical Structure : SRI-011381 hydrochloride

CAS No.: 2070014-88-7

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SRI-011381 hydrochloride (SRI011381 hydrochloride, C381 hydrochloride)

货号: PC-42107Not For Human Use, Lab Use Only.

SRI-011381 (C381) hydrochloride is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

SRI-011381 (C381) hydrochloride is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities.

C381 physically targets the lysosome, promotes lysosomal acidification, increases breakdown of lysosomal cargo, and improves lysosome resilience to damage.

C381 has the potential both as a therapeutic and as a research compound to better understand lysosomal contributions to disease progression.

C381 is an orally bioavailable and brain penetrant Smad activator found in phenotypic screen.

物理化学性质&存储条件

分子量	365.9406
分子式	C20H32ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N'-cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-,hydrochloride

参考文献

Ryan T Vest, et al. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2121609119.

SRI-011381 hydrochloride (SRI011381 hydrochloride, C381 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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SRI-011381 hydrochloride (SRI011381 hydrochloride, C381 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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