SR3335 | RORα inverse agonist | Probechem Biochemicals

Chemical Structure : SR3335

CAS No.: 293753-05-6

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SR3335 (SR-3335, ML 176, ML176)

货号: PC-26879Not For Human Use, Lab Use Only.

SR3335 (ML176) is a potent, selective RORα inverse agonist with binding Ki of 220 nM, significantly inhibits the constitutive transactivation activity of RORα with IC50 of 480 nM.

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25 mg	￥1480	In stock
50 mg	￥2480	In stock
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生物&药学活性

SR3335 (ML176) is a potent, selective RORα inverse agonist with binding Ki of 220 nM, significantly inhibits the constitutive transactivation activity of RORα with IC50 of 480 nM.
SR3335 also displays no activity on RORβ (radioligand binding or cotransfection assays), FXR (cotransfection assays) or any other receptors in a selectivity panel for human nuclear receptors.
SR3335 (5 uM) suppresses expression of both G6Pase and phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression in HepG2 cells.
SR3335 (15 mg/kg b.i.d., i.p.) suppresses gluconeogenesis in diet induced obese mice.

物理化学性质&存储条件

分子量	405.33
分子式	C13H9F6NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide

参考文献

1. Kumar N, et al. ACS Chem Biol. 2011 Mar 18;6(3):218-22.

2. Ito I, et al. J Leukoc Biol. 2017 Dec;102(6):1451-1460.

SR3335 (SR-3335, ML 176, ML176)

生物&药学活性

物理化学性质&存储条件

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SR3335 (SR-3335, ML 176, ML176)

生物&药学活性

物理化学性质&存储条件

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