SR1078

Chemical Structure : SR1078

CAS No.: 1246525-60-9

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货号: PC-24369Not For Human Use, Lab Use Only.

SR1078 a selective synthetic RORα/RORγ agonist / ligand, directly binds to the ligand binding domain of RORα and RORγ, increases the transcriptional activity.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

SR1078 a selective synthetic RORα/RORγ agonist / ligand, directly binds to the ligand binding domain of RORα and RORγ, increases the transcriptional activity.
SR1078 significantly inhibits the constitutive transactivation activity of RORα and RORγ, but has no effect on the activity of FXR, LXRα and LXRβ, in a cell-based chimeric receptor Gal4 DNA-binding domain – NR ligand binding domain cotransfection assay.
SR1078 dose-dependently activates RORα and RORγ in HepG2 cells that express both RORα and RORγ.
SR1078 activates ROR target gene transcription both in vitro and in vivo.

物理化学性质&存储条件

分子量	431.26
分子式	C17H10F9NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide

参考文献

1. Wang Y, et al. ACS Chem Biol. 2010 Nov 19;5(11):1029-34.

2. Wang Y, et al. PLoS One. 2012;7(4):e34921.

SR1078

生物&药学活性

物理化学性质&存储条件

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SR1078

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物理化学性质&存储条件

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