SQ-030 (SQ030)

Chemical Structure : SQ-030

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货号: PC-28337Not For Human Use, Lab Use Only.

SQ-030 is a potent, hepatocyte-specific cytosolic prostaglandin E synthase (cPGES) inhibitor with SPR KD of 0.315 uM.

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生物&药学活性

SQ-030 is a potent, hepatocyte-specific cytosolic prostaglandin E synthase (cPGES) inhibitor with SPR KD of 0.315 uM.
SQ-030 significantly reduces lipid accumulation in PA + OA-treated AML12 cells, while showing no apparent cytotoxicity across a concentration range of 0.01-100 μM in AML12 cells.
SQ-030 markedly alleviates liver dysfunction (serum AST and ALT), hepatic steatosis, inflammation and fibrosis, as shown by histology and by the expression of inflammatory and fibrotic markers in MCD-fed mice.
Cytosolic prostaglandin E synthase (cPGES, encoded by PTGES3) is a key enzyme in PGE2 synthesis, regulates MASLD and the synthesis of PGE2.

物理化学性质&存储条件

分子量	395.42
分子式	C21H21N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 6-methyl-2-oxo-4-(4-(2-oxo-2-(phenylamino)ethoxy)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

参考文献

1. Zhong D, et al. Cell Rep. 2026 Aug 27;45(9):117901.

SQ-030 (SQ030)

生物&药学活性

物理化学性质&存储条件

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SQ-030 (SQ030)

生物&药学活性

物理化学性质&存储条件

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