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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Renin-SPH3127
SPH3127

Chemical Structure : SPH3127

CAS No.: 1399849-02-5

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SPH3127 (Sitokiren, SPH-3127)

货号: PC-49361Not For Human Use, Lab Use Only.

SPH3127 (Sitokiren, SPH-3127) is a highly potent, selective and orally active renin inhibitor with IC50 of 0.4 and 0.45 nM for rh-renin and hPRA, respectively.

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10 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SPH3127 (Sitokiren, SPH-3127) is a highly potent, selective and orally active renin inhibitor with IC50 of 0.4 and 0.45 nM for rh-renin and hPRA, respectively.
SPH3127 demonstrated higher bioavailability and a more potent antihypertensive effect in preclinical models than aliskiren.

物理化学性质&存储条件

分子量 444.536
分子式 C22H32N6O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (3-(3-((R)-1-((R)-N-cyclopropylmorpholine-2-carboxamido)ethyl)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl)carbamate

参考文献

1. Iijima D, et al. J Med Chem. 2022 Aug 25;65(16):10882-10897.

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