SOFTI | SPINDLY inhibitor | Probechem Biochemicals

Chemical Structure : SOFTI

CAS No.: 1200133-34-1

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SOFTI (SPINDLY O-fucosyltransferase inhibitor, SPI-1)

货号: PC-21054Not For Human Use, Lab Use Only.

SOFTI is a small molecule inhibitor of O-fucosyltransferase SPINDLY (SPY) with IC50 of 13.32 uM, binds to the GDP-fucose-binding pocket of SPY and competitively inhibits GDP-fucose binding.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

SOFTI is a small molecule inhibitor of O-fucosyltransferase SPINDLY (SPY) with IC50 of 13.32 uM, binds to the GDP-fucose-binding pocket of SPY and competitively inhibits GDP-fucose binding.

SPY O-fucosyltransferase inhibitor (SOFTI) is a specific small molecule inhibitor of SPINDLY O-fucosyltransferase with KD of 37 uM in BLI assays.

SOFTI displays concentration-dependent inhibition of the self-fucosylation of recombinant 3TPR-SPY proteins with IC50 of 13.32 uM.

SOFTI has little effect on the O-fucosyltransferases in the endoplasmic reticulum.

物理化学性质&存储条件

分子量	497.74
分子式	C26H36KNO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(cyclohex-1-en-1-yl)-3-((1r,4R)-N-((1r,4R)-4-methoxycyclohexyl)-4-methylcyclohexane-1-carboxamido)thiophene-2-carboxylic acid

参考文献

1. Aizezi Y, et al. Plant Cell. 2023 Dec 20:koad299.

SOFTI (SPINDLY O-fucosyltransferase inhibitor, SPI-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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SOFTI (SPINDLY O-fucosyltransferase inhibitor, SPI-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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