Chemical Structure : SOD1 lactylation inhibitor ZL-01
CAS No.:
881591-33-9
SOD1 lactylation inhibitor ZL-01
货号: PC-26109Not For Human Use, Lab Use Only.
SOD1 lactylation inhibitor ZL-01 is a potential specifi inhibitor of csuperoxide dismutase 1 (SOD1) lactylation at lysine 123 (SOD1K123la), effectively reduces the SOD1K123la level and increases SOD1 activity.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
SOD1 lactylation inhibitor ZL-01 is a potential specifi inhibitor of csuperoxide dismutase 1 (SOD1) lactylation at lysine 123 (SOD1K123la), effectively reduces the SOD1K123la level and increases SOD1 activity.
ZL-01 primarily interacts with SOD1 residues Thr40, His44, and Lys123.
ZL-01 shows no significant effect on the acetylation and succinylation of SOD1 in nucleus pulposus cells (NPCs), effectively reduces SOD1K123la levels in lactate-treated NPCs, reverses the decreases in SOD1 enzymatic activity and T-AOC and decreases MDA levels.
ZL-01 rescued lactate-induced impairment of SOD1 function in SOD1 WT NPCs, but not in SOD1 function in SOD1 K123R NPCs.
NPCs-targeted ZL-01 delivery achieved effective intervertebral disc degeneration (IVDD) alleviation in rats.
物理化学性质&存储条件
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分子量
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234.26
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分子式
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C11H14N4O2
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-((1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)urea
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参考文献
1. Zhang Y, et al. Nat Commun. 2026 Feb 28. doi: 10.1038/s41467-026-69127-3.
