SNX631-6

Chemical Structure : SNX631-6

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货号: PC-24325Not For Human Use, Lab Use Only.

SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively.

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生物&药学活性

SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively.
SNX631-6 exhibits IC50 of 11.7 nM in cell-based NFκB-dependent reporter assay for CDK8/19 inhibition in wild type (WT) 293 cells, but not CDK8/19-double knockout (KO) 293 cells.
SNX631-6 inhibits cancer growth of MYC-CaP-CR tumors in isogenic FVB mice, with no detrimental effect on body weight.
SNX631-6 enhances the efficacy of platinum-based chemotherapy and paclitaxel in both platinum-sensitive and resistant OCCC cell lines.
SNX631-6 shows strong antitumor and anti-metastatic effects in vivo.

物理化学性质&存储条件

分子量	444.59
分子式	C22H20D6N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-4-(4-(4-(bis(methyl-d3)carbamoyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Li J, et al. J Clin Invest. 2024 Mar 28;134(10):e176709.

SNX631-6

生物&药学活性

物理化学性质&存储条件

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SNX631-6

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物理化学性质&存储条件

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