SNT-8370 | VAP-1/MPO inhibitor | Probechem Biochemicals

Chemical Structure : SNT-8370

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SNT-8370 (SNT8370)

货号: PC-24361Not For Human Use, Lab Use Only.

SNT-8370 is a potent, selective and irreversible dual inhibitor targeting vascular adhesion protein-1 (VAP-1) and myeloperoxidase (MPO) with IC50 of 10 nM and 17 nM respectively.

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生物&药学活性

SNT-8370 is a potent, selective and irreversible dual inhibitor targeting vascular adhesion protein-1 (VAP-1) and myeloperoxidase (MPO) with IC50 of 10 nM and 17 nM respectively.
SNT-8370 inhibited MPO-catalysed H2O2 consumption with IC50 of 0.08 uM, more significantly when compared to verdiperstat or PF06282999.
SNT-8370 also more efficiently inhibited MPO-catalysed HOCl production with IC50 of 0.25 uM, compared to verdiperstat or PF06282999.
SNT-8370 more potently inhibited MPO-mediated LDL lipid peroxidation (Fig. 3F), exhibiting an IC50 of 20 nM, 30-fold lower than the corresponding IC50 value for verdiperstat of 0.6 μM.
SNT-8370 exhibited a selectivity index of >100-fold over a panel of amine oxidase family, such as the monoamine oxidases, lysyl oxidases (LOX) and diamine oxidase (DAO).
SNT-8370 is metabolically stable, exhibits a favourable pharmacokinetic/pharmacodynamic profile without CNS penetration, and effectively inhibits VAP-1 and MPO activities.
SNT-8370 effectively inhibits leukocyte infiltration in mouse peritonitis, carrageenan air pouch, and lipopolysaccharide-induced lung injury models of acute inflammation.
SNT-8370 is also protective in preclinical models of myocardial ischemia-reperfusion injury and unilateral-ureteral-obstruction-induced nephropathy.

物理化学性质&存储条件

分子量	361.40
分子式	C16H16FN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3-((2-(aminomethyl)-3-fluoroallyl)oxy)benzyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one

参考文献

1. Glaros E, et al. Nat Commun. 2025 Apr 11;16(1):3430.

SNT-8370 (SNT8370)

生物&药学活性

物理化学性质&存储条件

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SNT-8370 (SNT8370)

生物&药学活性

物理化学性质&存储条件

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