SNJ-1945 | Calpain inhibitor | Probechem Biochemicals

Chemical Structure : SNJ-1945

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SNJ-1945 (Mitucapistat, SNJ1945)

货号: PC-26341Not For Human Use, Lab Use Only.

Mitucapistat (SNJ-1945) is potent, selective, reversible and orally available calpain inhibitor with IC50 of 86-190 nM range for m- and μ-calpain.

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生物&药学活性

Mitucapistat (SNJ-1945) is potent, selective, reversible and orally available calpain inhibitor with IC50 of 86-190 nM range for m- and μ-calpain.
SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells.
SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ and Rotenone.
SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis.

物理化学性质&存储条件

分子量	491.59
分子式	C25H37N3O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester

参考文献

1. Shimazawa M, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):380-7.

2. Koumura A, et al. Neuroscience. 2008 Nov 19;157(2):309-18.

3. Cuerrier D, et al. Biochemistry. 2006 Jun 20;45(24):7446-52.

SNJ-1945 (Mitucapistat, SNJ1945)

生物&药学活性

物理化学性质&存储条件

参考文献

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SNJ-1945 (Mitucapistat, SNJ1945)

生物&药学活性

物理化学性质&存储条件

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