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首页-小分子抑制剂&激动剂-Others-Pyruvate Kinase-SNH-119014
SNH-119014

Chemical Structure : SNH-119014

CAS No.: 2945151-67-5

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SNH-119014 (SNH119014)

货号: PC-26756Not For Human Use, Lab Use Only.

SNH-119014 is a novel allosteric Pyruvate kinase (PK) activator with AC50 of 28.9 nM for recombinant human PKLR, Emax of 949.9%.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SNH-119014 is a novel allosteric Pyruvate kinase (PK) activator with AC50 of 28.9 nM for recombinant human PKLR, Emax of 949.9%.
SNH-119014 increases the activity of PKLR and ATP levels in Red Blood Cell (RBC) to an extent comparable to AG-348.
SNH-119014 increased ATP levels, reduced ROS, and improved the GSH/GSSG ratio in erythroid precursors.

物理化学性质&存储条件

分子量 435.45
分子式 C20H19F2N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(2,4-difluorophenyl)-3-hydroxy-1-(1'-(pyridin-2-ylsulfonyl)-1',4'-dihydro-2H,2'H-[3,3'-biazetylidene]-1(4H)-yl)propan-1-one

参考文献

1. Huang Q, et al. Front Pharmacol. 2026 Apr 23;17:1719328.

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