SMY002 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : SMY002

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SMY002 (SMY-002)

货号: PC-24624Not For Human Use, Lab Use Only.

SMY002 is a potent novel small molecule STAT3 inhibitor, directly interacts and binds to STAT3 with SPR IC50 of 2 uM, inhibits the transcriptional activity of STAT3.

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生物&药学活性

SMY002 is a potent novel small molecule STAT3 inhibitor, directly interacts and binds to STAT3 with SPR IC50 of 2 uM, inhibits the transcriptional activity of STAT3.
SMY002 inhibits the phosphorylation and activation of STAT3 in 4T1, MDA-MB-231, and MDA-MB-468 cells.
SMY002 specifically suppress STAT3 activation, not by inhibiting its upstream kinase JAK2 or other off-target effects but by directly interfering with STAT3 phosphorylation.
SMY002 induces apoptosis and cycle blockage in TNBC cells.
SMY002 attenuates the migration and invasion of TNBC cells in vitro.
SMY002 prevents xenograft TNBC cell growth and dissemination.

物理化学性质&存储条件

分子量	376.50
分子式	C24H28N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-(2-(piperidin-1-yl)ethoxy)benzyl)oxy)naphthalen-1-amine

参考文献

1. Zhengyan Yang, et al. Breast Cancer Res Treat. 2023 Jan;197(2):255-267.

SMY002 (SMY-002)

生物&药学活性

物理化学性质&存储条件

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SMY002 (SMY-002)

生物&药学活性

物理化学性质&存储条件

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