SMS2 inhibitor Ly93

Chemical Structure : SMS2 inhibitor Ly93

CAS No.: 1883528-69-5

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货号: PC-24450Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SMS2 inhibitor Ly93 is a potent, selective, orally efficacious sphingomyelin synthase 2 (SMS2) inhibitor with IC50 of 91 nM, >1000-fold selective over SMS1, demonstrates anti-atherosclerotic activities in vivo.
Ly93 not only dose-dependently diminished apoB secretion from Huh7 cells, but also significantly reduced the SMS activity and increased cholesterol efflux from macrophages.
Ly93 significantly decreased the plasma SM levels of C57BL/6J mice.
Ly93 capable of dose-dependently attenuating the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions.

物理化学性质&存储条件

分子量	332.40
分子式	C21H20N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-Ethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide

参考文献

1. Yali Li, et al. Eur J Med Chem. 2019 Feb 1:163:864-882.