SMS2 inhibitor 14l

Chemical Structure : SMS2 inhibitor 14l

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货号: PC-24449Not For Human Use, Lab Use Only.

SMS2 inhibitor 14l is a highly potent and selective sphingomyelin synthase 2 (SMS2) inhibitor with IC50 of 28 nM (sphingomyelin (SM) synthesis), with no activity against SMS1 (IC50=16 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SMS2 inhibitor 14l is a highly potent and selective sphingomyelin synthase 2 (SMS2) inhibitor with IC50 of 28 nM (sphingomyelin (SM) synthesis), with no activity against SMS1 (IC50=16 uM).
SMS2 inhibitor 14l strongly inhibits the SM synthesis in HCEC with an EC50 value of 300 nM.
SMS2 inhibitor 14l exhibits a notable protective effect of anti-inflammation and anti-apoptosis on human corneal epithelial cells (HCEC) under TNF-α-hyperosmotic stress conditions in vitro.
SMS2 inhibitor 14l alleviated the dry eye symptoms including corneal fluorescein staining scores and tear secretion in a dose-dependent manner in mice.
SMS2 inhibitor 14l reduced the mRNA expression of Tnf-α, Il-1β and Mmp-9 in corneas, as well as the proportion of very long chain SM in meibomian glands.

物理化学性质&存储条件

分子量	438.59
分子式	C25H30N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2-(Octyloxy)benzyl)oxy)-N-(pyridin-3-yl)thiophene-2-carboxamide

参考文献

1. Yang J, et al. Acta Pharm Sin B. 2025 Jan;15(1):392-408.