SMER-18 |CAS:944153-47-3 Probechem Biochemicals

Chemical Structure : SMER-18

CAS No.: 944153-47-3

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SMER-18 (SMER18)

货号: PC-45515Not For Human Use, Lab Use Only.

SMER-18 is a small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein.

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生物&药学活性

SMER-18 is a small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein.
SMER-18 reduces toxicity in Huntington's disease models.

物理化学性质&存储条件

分子量	287.7409
分子式	C16H14ClNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-

参考文献

1. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.

SMER-18 (SMER18)

生物&药学活性

物理化学性质&存储条件

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SMER-18 (SMER18)

生物&药学活性

物理化学性质&存储条件

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