SMC247-9 hydrochloride | APOBEC3B inhibitor | Probechem Biochemicals

Chemical Structure : SMC247-9 hydrochloride

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SMC247-9 hydrochloride (SMC 247-9 hydrochloride)

货号: PC-28116Not For Human Use, Lab Use Only.

SMC247-9 hydrochloride is a highly potent inhibitor of single-stranded DNA cytosine-to-uracil deaminase APOBEC3B (A3B) inhibitor with IC50 of 50 pM and MST KD of 300 pM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SMC247-9 hydrochloride is a highly potent inhibitor of single-stranded DNA cytosine-to-uracil deaminase APOBEC3B (A3B) inhibitor with IC50 of 50 pM and MST KD of 300 pM.
SMC247-9 reduces cellular A3B abundance and promotes IL-15 expression in tumor cells.
SMC247-9 reduces cellular A3B abundance and promoted IL-15 expression in tumor cells, thereby relieving tumor cell-mediated suppression of CD8+ T cells in an IL-15-dependent manner.
SMC247-9 suppresses tumor growth in the immune checkpoint blockade (ICB)-responsive MC38 model and synergized with anti-PD-L1 in the ICB-resistant TC-1 model.
SMC247-9 also attenuates macrophage chemotaxis and ameliorates anti-PD-1-exacerbated DSS-induced colitis-like intestinal inflammation.

物理化学性质&存储条件

分子量	245.70
分子式	C11H16ClNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-3-(4-hydroxy-3,5-dimethylphenyl)propanoic acid hydrochloride

参考文献

1. Ning H, et al. J Med Chem. 2026 Sep 10;69(17):20678-20697.

SMC247-9 hydrochloride (SMC 247-9 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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SMC247-9 hydrochloride (SMC 247-9 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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