SM875

Chemical Structure : SM875

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货号: PC-24687Not For Human Use, Lab Use Only.

SM875 is a small molecule prion (PrP) protein degrader, decreases the levels of PrP in HEK293 cells with IC50 of 7.87 uM.

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100 mg		Get quote

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生物&药学活性

SM875 is a small molecule prion (PrP) protein degrader, decreases the levels of PrP in HEK293 cells with IC50 of 7.87 uM.
SM875 (1-30 uM) decreased PrP levels in a dose-dependent fashion in human breast cancer cell line (ZR-75) endogenously expressing human PrP.
SM875 induces the degradation of PrP by the lysosomes. SM875 acts exclusively on non-native, newly synthesized PrP.
SM875 suppresses prion replication in mouse L929 fibroblasts, induces the aggregation of partially denatured PrP.

物理化学性质&存储条件

分子量	414.26
分子式	C19H16BrN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-bromophenyl)-1,4,5,7-tetrahydro-4-(4-hydroxy-3)-6H-pyrazolo[3,4-b]pyridin-6-one

参考文献

1. Spagnolli G, et al. Commun Biol. 2021 Jan 12;4(1):62.

SM875

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物理化学性质&存储条件

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SM875

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